Rett syndrome is a dominant neurological disorder caused by loss-of-function mutations of
methyl-CpG-binding protein 2 (MeCP2). MeCP2 is an abundant chromatin-associated …

The methyl-CpG-binding protein 2 (MECP2) serves both organizational and transcriptional
functions in the nucleus, with two well-characterized domains integrally related to these …

Mutations of the methylated DNA binding protein MeCP2, a multifunctional protein that is
thought to transmit epigenetic information encoded as methylated CpG dinucleotides to the …

Abstract Methylated CpG Binding Protein 2 (MeCP2) is a nuclear protein named for its ability
to selectively recognize methylated DNA. Much attention has been focused on …

Since the discovery of its fundamental involvement in Rett syndrome, methyl CpG binding
protein 2 (MeCP2) has been the focus of an exhaustive biochemical and functional …

MeCP2 is a methyl‐CpG binding protein that can repress transcription of nearby genes. In
humans, mutations in the MECP2 gene are the major cause of Rett syndrome. By searching …

Sporadic mutations in the hMeCP2 gene, coding for a protein that preferentially binds
symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome …

Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause several
neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the …

Me CP 2 is a chromatin‐associated protein that is mutated in Rett syndrome. Its methyl‐CpG‐
binding domain interacts with DNA containing methylated cytosine, but other modes of …

Abstract Methyl CpG-binding protein 2 (MeCP2), the mutated protein in Rett syndrome
(RTT), is a crucial chromatin-modifying and gene-regulatory protein that has two main …