Rett syndrome is a neuropsychiatric disorder with onset in early childhood. Loss-of-function
mutations of the X-linked gene encoding methyl-CpG binding protein 2 (MECP2) are …

Mutations in the MECP2 gene cause Rett syndrome (RTT). MeCP2 binds to chromocentric
DNA through its methyl CpG-binding domain (MBD) to regulate gene expression. In …

Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-
associated multifunctional protein, how MeCP2 integrates external signals and regulates …

Rett syndrome is a severe neurodevelopmental disorder caused by mutations in the methyl-
CpG binding protein gene (MECP2). MeCP2 is a methyl-cytosine binding protein that is …

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl-
CpG-binding protein 2 (MECP2) gene. Previous data have shown that MECP2 RNA is …

It has been a long trip from 1992, the year of the discovery of MECP2, to the present day.
What is surprising is that some of the pivotal roles of MeCP2 were already postulated at that …

Methylation of cytosine in human DNA has been studied for over 60 years, but has only
recently been confirmed as an important player in human disease. Rett syndrome is a …

Rett syndrome (RTT) is a neurodevelopmental disorder caused predominantly by loss-of-
function mutations in the gene Methyl-CpG-binding protein 2 (MECP2), which encodes the …

Rett syndrome is a neurodevelopmental disorder that primarily affects females and is
caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 …

Most cases of Rett syndrome (RTT) are caused by mutations in the methylated DNA-binding
protein, MeCP2. Here, we have shown that frequent RTT-causing missense mutations …