Mutations of X-linked gene Methyl CpG binding protein 2 (MECP2) are the major causes of
Rett syndrome (RTT), a severe neurodevelopmental disorder. Duplications of MECP2 …

The role of epigenetics in human disease has become an area of increased research
interest. Collaborative efforts from scientists and clinicians have led to a better …

Rett Syndrome (RTT) is a severe, rare, and progressive developmental disorder with
patients displaying neurological regression and autism spectrum features. The affected …

Background Rett syndrome (RTT) is a complex neurological disorder that is one of the most
frequent causes of mental retardation in women. A great landmark in research in this field …

MeCP2 is a fundamental protein associated with several neurological disorders, including
Rett syndrome. It is considered a multifunctional factor with a prominent role in regulating …

Rett syndrome (RTT) is a disorder that affects patients' ability to communicate, move and
behave. RTT patients are characterized by impaired language, stereotypic behaviors …

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in MECP2,
encoding methyl-CpG-binding protein 2 (MeCP2). Although MECP2 is ubiquitously …

Mecp2 is an X-linked gene encoding a nuclear protein that binds specifically to methylated
DNA (ref. 1) and functions as a general transcriptional repressor by associating with …

The discovery in 1999 that Rett syndrome (RTT) is caused by mutations in a gene encoding
the methyl-CpG-binding repressor protein MECP2 provided a significant breakthrough in the …

Mutations in the X-linked MECP2 cause Rett syndrome, a devastating neurological disorder
typified by a period of apparently normal development followed by loss of cognitive and …