Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI
The effect of carbon dioxide (CO2) on cerebral metabolism is of tremendous interest to
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …
Sources of systematic bias in hypercapnia-calibrated functional MRI estimation of oxygen metabolism
The change in cerebral rate of oxidative metabolism (CMRO2) during neural activation may
be estimated from blood oxygenation level-dependent (BOLD) functional magnetic …
be estimated from blood oxygenation level-dependent (BOLD) functional magnetic …
Measurement of OEF and absolute CMRO2: MRI-based methods using interleaved and combined hypercapnia and hyperoxia
Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI)
is most commonly used in a semi-quantitative manner to infer changes in brain activity …
is most commonly used in a semi-quantitative manner to infer changes in brain activity …
Improved fMRI calibration: precisely controlled hyperoxic versus hypercapnic stimuli
The calibration of functional magnetic resonance imaging (fMRI) for the estimation of
neuronal activation-induced changes in cerebral metabolic rate of oxygen (CMRO2) has …
neuronal activation-induced changes in cerebral metabolic rate of oxygen (CMRO2) has …
Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease
JJ Chen, B Uthayakumar… - Journal of Cerebral Blood …, 2022 - journals.sagepub.com
Conventional functional MRI (fMRI) with blood-oxygenation level dependent (BOLD)
contrast is an important tool for mapping human brain activity non-invasively. Recent interest …
contrast is an important tool for mapping human brain activity non-invasively. Recent interest …
The influence of carbon dioxide on brain activity and metabolism in conscious humans
A better understanding of carbon dioxide (CO2) effect on brain activity may have a profound
impact on clinical studies using CO2 manipulation to assess cerebrovascular reserve and …
impact on clinical studies using CO2 manipulation to assess cerebrovascular reserve and …
[HTML][HTML] Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism
R Buxton - Frontiers in neuroenergetics, 2010 - frontiersin.org
Functional magnetic resonance imaging (fMRI) is widely used to map patterns of brain
activation based on blood oxygenation level dependent (BOLD) signal changes associated …
activation based on blood oxygenation level dependent (BOLD) signal changes associated …
A novel method of quantifying hemodynamic delays to improve hemodynamic response, and CVR estimates in CO2 challenge fMRI
Elevated carbon dioxide (CO2) in breathing air is widely used as a vasoactive stimulus to
assess cerebrovascular functions under hypercapnia (ie,“stress test” for the brain). Blood …
assess cerebrovascular functions under hypercapnia (ie,“stress test” for the brain). Blood …
[HTML][HTML] Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration
A Merola, K Murphy, AJ Stone, MA Germuska… - Neuroimage, 2016 - Elsevier
Several techniques have been proposed to estimate relative changes in cerebral metabolic
rate of oxygen consumption (CMRO 2) by exploiting combined BOLD fMRI and cerebral …
rate of oxygen consumption (CMRO 2) by exploiting combined BOLD fMRI and cerebral …
High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states
M Xu, B Bo, M Pei, Y Chen, CY Shu… - Journal of Cerebral …, 2022 - journals.sagepub.com
Functional magnetic resonance imaging (fMRI) techniques using the blood-oxygen level-
dependent (BOLD) signal have shown great potential as clinical biomarkers of disease …
dependent (BOLD) signal have shown great potential as clinical biomarkers of disease …