The blood-oxygenation-level-dependent (BOLD) signal is an indirect hemodynamic signal
that is sensitive to cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral …

Functional magnetic resonance imaging (fMRI) is an essential workhorse of modern
neuroscience, providing valuable insight into the functional organisation of the brain. The …

Investigations into the blood oxygenation level-dependent (BOLD) functional MRI signal
have used respiratory challenges with the aim of probing cerebrovascular physiology. Such …

Dual-calibrated fMRI is a multi-parametric technique that allows for the quantification of the
resting oxygen extraction fraction (OEF), the absolute rate of cerebral metabolic oxygen …

We present a method allowing determination of resting cerebral oxygen metabolism
(CMRO2) from MRI and end-tidal O2 measurements acquired during a pair of respiratory …

Estimation of the cerebral metabolic rate of oxygen (CMRO 2) and cerebral blood flow (CBF)
is important to investigate the neurovascular coupling and physiological components in …

Measuring the global cerebral metabolic rate of oxygen (CMRO 2) is a valuable tool for
assessing brain vitality and function. Measurement of blood oxygen saturation (HbO 2) and …

Changes in cerebral blood flow (CBF), volume (CBV), and oxygenation (blood-oxygenation
level dependent (BOLD)) during functional activation are important for calculating changes …

The brain depends almost entirely on oxidative metabolism to meet its significant energy
requirements. As such, the cerebral metabolic rate of oxygen (CMRO2) represents a key …

We have recently described an extension of calibrated MRI, which we term QUO2 (for
QUantitative O2 imaging), providing absolute quantification of resting oxidative metabolism …