We have recently described an extension of calibrated MRI, which we term QUO2 (for
QUantitative O2 imaging), providing absolute quantification of resting oxidative metabolism …

The brain depends almost entirely on oxidative metabolism to meet its significant energy
requirements. As such, the cerebral metabolic rate of oxygen (CMRO2) represents a key …

In conventional neuroimaging, cerebrovascular reactivity (CVR) is quantified primarily using
the blood-oxygenation level-dependent (BOLD) functional MRI (fMRI) signal, specifically, as …

The coupling between cerebral blood flow (CBF) and cerebral metabolic rate of oxygen
(CMRO2) during brain activation can be characterized by an empirical index n, the ratio of …

Hypercapnia is often used as vasodilatory challenge in clinical applications and basic
research. In functional magnetic resonance imaging (fMRI), elevated CO2 is applied to …

The measurement of the absolute rate of cerebral metabolic oxygen consumption (CMRO 2)
is likely to offer a valuable biomarker in many brain diseases and could prove to be …

The estimation of changes in CMRO2 using functional MRI involves an essential calibration
step using a vasoactive agent to induce an isometabolic change in CBF. This calibration …

MRI was extended to the measurement of changes in oxidative metabolism in the normal
human during functionally induced changes in cellular activity. A noninvasive MRI method …

The relationship between localized changes in brain activity and metabolism, and the blood
oxygenation level‐dependent (BOLD) signal used in functional magnetic resonance …

Characterizing the effect of oxygen (O2) modulation on the brain may provide a better
understanding of several clinically relevant problems, including acute mountain sickness …