Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: a calibrated BOLD fMRI study

JE Perthen, AE Lansing, J Liau, TT Liu, RB Buxton - Neuroimage, 2008 - Elsevier
Although functional MRI (fMRI) based on blood oxygenation level-dependent (BOLD) signal
changes is a sensitive tool for mapping brain activation, quantitative studies of the …

MRI measurement of the BOLD-specific flow–volume relationship during hypercapnia and hypocapnia in humans

JJ Chen, GB Pike - Neuroimage, 2010 - Elsevier
It is widely assumed in fMRI that the relationship between cerebral blood flow (CBF) and
volume (CBV) changes observed during end-tidal CO2 (PETCO2) perturbations is …

Assessment of cerebral oxidative metabolism with breath holding and fMRI

A Kastrup, G Krüger, GH Glover… - Magnetic Resonance in …, 1999 - Wiley Online Library
Carbon dioxide inhalation can be used to map changes in cerebral metabolic rate of oxygen
(CMRo2) during neuronal activation with functional MRI (fMRI). A hypercapnic stress also …

A generalized procedure for calibrated MRI incorporating hyperoxia and hypercapnia

CJ Gauthier, RD Hoge - Human brain mapping, 2013 - Wiley Online Library
Calibrated MRI techniques use the changes in cerebral blood flow (CBF) and blood
oxygenation level‐dependent (BOLD) signal evoked by a respiratory manipulation to …

Determination of relative CMRO2 from CBF and BOLD changes: Significant increase of oxygen consumption rate during visual stimulation

SG Kim, E Rostrup, HBW Larsson… - … in Medicine: An …, 1999 - Wiley Online Library
The blood oxygenation level‐dependent (BOLD) effect in functional magnetic resonance
imaging depends on at least partial uncoupling between cerebral blood flow (CBF) and …

Mapping the end-tidal CO2 response function in the resting-state BOLD fMRI signal: Spatial specificity, test–retest reliability and effect of fMRI sampling rate

AM Golestani, C Chang, JB Kwinta, YB Khatamian… - Neuroimage, 2015 - Elsevier
The blood oxygenation level dependent (BOLD) signal measures brain function indirectly
through physiological processes and hence is susceptible to global physiological changes …

Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal

RG Wise, K Ide, MJ Poulin, I Tracey - Neuroimage, 2004 - Elsevier
Carbon dioxide is a potent cerebral vasodilator. We have identified a significant source of
low-frequency variation in blood oxygen level-dependent (BOLD) magnetic resonance …

High-Resolution CMRO2 Mapping in Rat Cortex: A Multiparametric Approach to Calibration of BOLD Image Contrast at 7 Tesla

I Kida, RP Kennan, DL Rothman… - Journal of Cerebral …, 2000 - journals.sagepub.com
The blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging
(fMRI) method, which is sensitive to vascular paramagnetic deoxyhemoglobin, is dependent …

Accounting for the role of hematocrit in between‐subject variations of MRI‐derived baseline cerebral hemodynamic parameters and functional BOLD responses

F Xu, W Li, P Liu, J Hua, JJ Strouse… - Human brain …, 2018 - Wiley Online Library
Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF)
and between‐subject variation of Hct thus causes variation in task‐based BOLD fMRI signal …

Impact of baseline CO2 on Blood-Oxygenation-Level-Dependent MRI measurements of cerebrovascular reactivity and task-evoked signal activation

CHB van Niftrik, M Piccirelli, O Bozinov… - Magnetic resonance …, 2018 - Elsevier
Neurovascular coupling describes the cascade between neuronal activity and subsequent
Blood-Oxygenation-Level-Dependent (BOLD) signal increase. Based on this premise, the …