Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, p …

M DiNuzzo, GA Dienel, KL Behar… - Journal of …, 2024 - Wiley Online Library
During transient brain activation cerebral blood flow (CBF) increases substantially more than
cerebral metabolic rate of oxygen consumption (CMRO2) resulting in blood …

Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice

XH Zhu, JM Chen, TW Tu, W Chen, SK Song - Neuroimage, 2013 - Elsevier
Many brain diseases have been linked to abnormal oxygen metabolism and blood
perfusion; nevertheless, there is still a lack of robust diagnostic tools for directly imaging …

[HTML][HTML] The role of cerebrovascular-reactivity mapping in functional MRI: calibrated fMRI and resting-state fMRI

JJ Chen, CJ Gauthier - Frontiers in physiology, 2021 - frontiersin.org
Task and resting-state functional MRI (fMRI) is primarily based on the same blood-
oxygenation level-dependent (BOLD) phenomenon that MRI-based cerebrovascular …

MRI measurement of the temporal evolution of relative CMRO2 during rat forepaw stimulation

JB Mandeville, JJA Marota, C Ayata… - … in Medicine: An …, 1999 - Wiley Online Library
This study reports the first measurement of the relative cerebral metabolic rate of oxygen
utilization (rCMRO2) during functional brain activation with sufficient temporal resolution to …

Assessment of cerebrovascular reactivity with functional magnetic resonance imaging: comparison of CO2 and breath holding

A Kastrup, G Krüger, T Neumann-Haefelin… - Magnetic resonance …, 2001 - Elsevier
Cerebral blood flow (CBF) and oxygenation changes following both a simple breath holding
test (BHT) and a CO2 challenge can be detected with functional magnetic resonance …

Cerebral blood flow and BOLD fMRI responses to hypoxia in awake and anesthetized rats

TQ Duong - Brain research, 2007 - Elsevier
This study investigated the functional MRI responses to graded hypoxia in awake/restrained
and anesthetized animals by measuring cerebral blood flow (CBF) and blood oxygenation …

Test–retest reproducibility of a rapid method to measure brain oxygen metabolism

P Liu, F Xu, H Lu - Magnetic resonance in medicine, 2013 - Wiley Online Library
Cerebral metabolic rate of oxygen (CMRO2) is an important index of tissue viability and
brain function, but this parameter cannot yet be measured routinely on clinical scanners …

Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: the deoxyhemoglobin dilution model

RD Hoge, J Atkinson, B Gill, GR Crelier… - … in Medicine: An …, 1999 - Wiley Online Library
The relationship between blood oxygenation level‐dependent (BOLD) MRI signals, cerebral
blood flow (CBF), and oxygen consumption (CMRO2) in the physiological steady state was …

Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation

MA Yaseen, VJ Srinivasan, S Sakadžić… - Journal of Cerebral …, 2011 - journals.sagepub.com
Measuring cerebral oxygen delivery and metabolism microscopically is important for
interpreting macroscopic functional magnetic resonance imaging (fMRI) data and identifying …

[HTML][HTML] Mapping the pharmacological modulation of brain oxygen metabolism: The effects of caffeine on absolute CMRO2 measured using dual calibrated fMRI

A Merola, MA Germuska, EAH Warnert, L Richmond… - Neuroimage, 2017 - Elsevier
This study aims to map the acute effects of caffeine ingestion on grey matter oxygen
metabolism and haemodynamics with a novel MRI method. Sixteen healthy caffeine …