Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, p …
M DiNuzzo, GA Dienel, KL Behar… - Journal of …, 2024 - Wiley Online Library
During transient brain activation cerebral blood flow (CBF) increases substantially more than
cerebral metabolic rate of oxygen consumption (CMRO2) resulting in blood …
cerebral metabolic rate of oxygen consumption (CMRO2) resulting in blood …
Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice
Many brain diseases have been linked to abnormal oxygen metabolism and blood
perfusion; nevertheless, there is still a lack of robust diagnostic tools for directly imaging …
perfusion; nevertheless, there is still a lack of robust diagnostic tools for directly imaging …
[HTML][HTML] The role of cerebrovascular-reactivity mapping in functional MRI: calibrated fMRI and resting-state fMRI
JJ Chen, CJ Gauthier - Frontiers in physiology, 2021 - frontiersin.org
Task and resting-state functional MRI (fMRI) is primarily based on the same blood-
oxygenation level-dependent (BOLD) phenomenon that MRI-based cerebrovascular …
oxygenation level-dependent (BOLD) phenomenon that MRI-based cerebrovascular …
MRI measurement of the temporal evolution of relative CMRO2 during rat forepaw stimulation
JB Mandeville, JJA Marota, C Ayata… - … in Medicine: An …, 1999 - Wiley Online Library
This study reports the first measurement of the relative cerebral metabolic rate of oxygen
utilization (rCMRO2) during functional brain activation with sufficient temporal resolution to …
utilization (rCMRO2) during functional brain activation with sufficient temporal resolution to …
Assessment of cerebrovascular reactivity with functional magnetic resonance imaging: comparison of CO2 and breath holding
A Kastrup, G Krüger, T Neumann-Haefelin… - Magnetic resonance …, 2001 - Elsevier
Cerebral blood flow (CBF) and oxygenation changes following both a simple breath holding
test (BHT) and a CO2 challenge can be detected with functional magnetic resonance …
test (BHT) and a CO2 challenge can be detected with functional magnetic resonance …
Cerebral blood flow and BOLD fMRI responses to hypoxia in awake and anesthetized rats
TQ Duong - Brain research, 2007 - Elsevier
This study investigated the functional MRI responses to graded hypoxia in awake/restrained
and anesthetized animals by measuring cerebral blood flow (CBF) and blood oxygenation …
and anesthetized animals by measuring cerebral blood flow (CBF) and blood oxygenation …
Test–retest reproducibility of a rapid method to measure brain oxygen metabolism
Cerebral metabolic rate of oxygen (CMRO2) is an important index of tissue viability and
brain function, but this parameter cannot yet be measured routinely on clinical scanners …
brain function, but this parameter cannot yet be measured routinely on clinical scanners …
Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: the deoxyhemoglobin dilution model
RD Hoge, J Atkinson, B Gill, GR Crelier… - … in Medicine: An …, 1999 - Wiley Online Library
The relationship between blood oxygenation level‐dependent (BOLD) MRI signals, cerebral
blood flow (CBF), and oxygen consumption (CMRO2) in the physiological steady state was …
blood flow (CBF), and oxygen consumption (CMRO2) in the physiological steady state was …
Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation
Measuring cerebral oxygen delivery and metabolism microscopically is important for
interpreting macroscopic functional magnetic resonance imaging (fMRI) data and identifying …
interpreting macroscopic functional magnetic resonance imaging (fMRI) data and identifying …
[HTML][HTML] Mapping the pharmacological modulation of brain oxygen metabolism: The effects of caffeine on absolute CMRO2 measured using dual calibrated fMRI
A Merola, MA Germuska, EAH Warnert, L Richmond… - Neuroimage, 2017 - Elsevier
This study aims to map the acute effects of caffeine ingestion on grey matter oxygen
metabolism and haemodynamics with a novel MRI method. Sixteen healthy caffeine …
metabolism and haemodynamics with a novel MRI method. Sixteen healthy caffeine …