Stimulus evoked changes in cerebral blood flow, volume, and oxygenation arise from
responses to underlying neuronally mediated changes in vascular tone and cerebral oxygen …

Cerebrovascular reactivity (CVR) is an important metric of cerebrovascular health. While the
BOLD fMRI method in conjunction with carbon-dioxide (CO 2) based vascular manipulation …

Purpose Our objective was to demonstrate the feasibility of using hyperventilation as an
efficient vasoconstrictive challenge and prior knowledge as denoising constraints for …

The coupling of changes in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen
(CMRO2) during brain activation can be characterized by an empirical index, n, defined as …

Recent blood oxygenation level–dependent (BOLD) functional magnetic resonance imaging
studies have shown a reduction of cerebral activation during aging, which may be …

Understanding cerebrovascular responses to hyperoxia and hypercapnia is important for
investigating exogenous regulation of cerebral hemodynamics. We characterized gas …

The amplitude of the BOLD response to a stimulus is not only determined by changes in
cerebral blood flow (CBF) and oxygen metabolism (CMRO2), but also by baseline …

To assess cerebral energetics in transgenic mouse models of neurologic disease, a robust,
efficient, and practical method for quantification of cerebral oxygen consumption is needed …

Abstract Although BOLD functional MRI (fMRI) provides a useful tool for probing neuronal
activities, large intersubject variations in signal amplitude are commonly observed …

Functional magnetic resonance imaging typically measures signal increases arising from
changes in the transverse relaxation rate over small regions of the brain and associates …