Most functional magnetic resonance imaging (fMRI) studies in animals are conducted under
anesthesia to minimize motion artifacts. However, methods and techniques have been …

Measuring the global cerebral metabolic rate of oxygen (CMRO 2) is a valuable tool for
assessing brain vitality and function. Measurement of blood oxygen saturation (HbO 2) and …

Dual-calibrated fMRI is a multi-parametric technique that allows for the quantification of the
resting oxygen extraction fraction (OEF), the absolute rate of cerebral metabolic oxygen …

Acute hypercapnia simultaneously induces increases in regional cerebral blood volume
(rCBV) and the oxygen saturation of cerebral venous blood (Yv). Changes in both …

Calibrated MRI techniques use the changes in cerebral blood flow (CBF) and blood
oxygenation level‐dependent (BOLD) signal evoked by a respiratory manipulation to …

Background There is a real need for quantifiable neuro-imaging biomarkers in concussion.
Here we outline a brain BOLD-MRI CO2 stress test to assess the condition. Methods This …

This study investigated the functional MRI responses to graded hypoxia in awake/restrained
and anesthetized animals by measuring cerebral blood flow (CBF) and blood oxygenation …

The brain depends on a continuous supply of oxygen to maintain its structural and functional
integrity. This study measured T 1 from MRI under normobaric air, normobaric oxygen …

The blood-oxygenation-level-dependent (BOLD) signal is an indirect hemodynamic signal
that is sensitive to cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral …

Conflicting results reported on the effects of hyperoxia on cerebral hemodynamics have
been attributed mainly to methodical and species differences. In the present study contrast …