Absolute quantification of resting oxygen metabolism and metabolic reactivity during functional activation using QUO2 MRI
CJ Gauthier, L Desjardins-Crépeau, C Madjar… - Neuroimage, 2012 - Elsevier
We have recently described an extension of calibrated MRI, which we term QUO2 (for
QUantitative O2 imaging), providing absolute quantification of resting oxidative metabolism …
QUantitative O2 imaging), providing absolute quantification of resting oxidative metabolism …
Functional MRI of CO2 induced increase in cerebral perfusion
The sensitivity of MR gradient echo imaging towards CO2 induced changes in cerebral
blood flow was investigated in 10 normal subjects. The subjects were inhaling 5% and 7 …
blood flow was investigated in 10 normal subjects. The subjects were inhaling 5% and 7 …
[HTML][HTML] Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration
A Merola, K Murphy, AJ Stone, MA Germuska… - Neuroimage, 2016 - Elsevier
Several techniques have been proposed to estimate relative changes in cerebral metabolic
rate of oxygen consumption (CMRO 2) by exploiting combined BOLD fMRI and cerebral …
rate of oxygen consumption (CMRO 2) by exploiting combined BOLD fMRI and cerebral …
[HTML][HTML] Graded hypercapnia-calibrated BOLD: beyond the iso-metabolic hypercapnic assumption
ID Driver, RG Wise, K Murphy - Frontiers in neuroscience, 2017 - frontiersin.org
Calibrated BOLD is a promising technique that overcomes the sensitivity of conventional
fMRI to the cerebrovascular state; measuring either the basal level, or the task-induced …
fMRI to the cerebrovascular state; measuring either the basal level, or the task-induced …
Quantitative measurements of cerebral blood oxygen saturation using magnetic resonance imaging
A quantitative estimate of cerebral blood oxygen saturation is of critical importance in the
investigation of cerebrovascular disease because of the fact that it could potentially provide …
investigation of cerebrovascular disease because of the fact that it could potentially provide …
Comparison of CO2 in Air Versus Carbogen for the Measurement of Cerebrovascular Reactivity with Magnetic Resonance Imaging
HV Hare, M Germuska, ME Kelly… - Journal of Cerebral …, 2013 - journals.sagepub.com
Measurement of cerebrovascular reactivity (CVR) can give valuable information about
existing pathology and the risk of adverse events, such as stroke. A common method of …
existing pathology and the risk of adverse events, such as stroke. A common method of …
Noninvasive imaging of quantitative cerebral blood flow changes during 100% oxygen inhalation using arterial spin-labeling MR imaging
G Zaharchuk, AJ Martin… - American Journal of …, 2008 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Tracer studies have demonstrated that 100% oxygen
inhalation causes a small cerebral blood flow (CBF) decrease. This study was performed to …
inhalation causes a small cerebral blood flow (CBF) decrease. This study was performed to …
Calibrated fMRI for dynamic mapping of CMRO2 responses using MR-based measurements of whole-brain venous oxygen saturation
EK Englund, MA Fernández-Seara… - Journal of Cerebral …, 2020 - journals.sagepub.com
Functional MRI (fMRI) can identify active foci in response to stimuli through BOLD signal
fluctuations, which represent a complex interplay between blood flow and cerebral …
fluctuations, which represent a complex interplay between blood flow and cerebral …
MRI measurement of the BOLD-specific flow–volume relationship during hypercapnia and hypocapnia in humans
It is widely assumed in fMRI that the relationship between cerebral blood flow (CBF) and
volume (CBV) changes observed during end-tidal CO2 (PETCO2) perturbations is …
volume (CBV) changes observed during end-tidal CO2 (PETCO2) perturbations is …
[HTML][HTML] The role of cerebrovascular-reactivity mapping in functional MRI: calibrated fMRI and resting-state fMRI
JJ Chen, CJ Gauthier - Frontiers in physiology, 2021 - frontiersin.org
Task and resting-state functional MRI (fMRI) is primarily based on the same blood-
oxygenation level-dependent (BOLD) phenomenon that MRI-based cerebrovascular …
oxygenation level-dependent (BOLD) phenomenon that MRI-based cerebrovascular …