DNA methylation is an epigenetic mark associated with transcriptional repression and
essential for proper vertebrate development. Because of its association with human …

Genomic DNA methylation functions to repress gene expression by interfering with
transcription factor binding and/or recruiting repressive chromatin machinery. Recent data …

DNA methylation occurs on cytosines, is catalyzed by DNA methyltransferases (DNMTs),
and is present at high levels in all vertebrates. DNA methylation plays essential roles in …

Methylation of cytosines in the CG context (mCG) is the most abundant DNA modification in
vertebrates that plays crucial roles in cellular differentiation and identity. After fertilization …

DNA methylation reprogramming, the erasure of DNA methylation patterns shortly after
fertilization and their reestablishment during subsequent early development, is essential for …

DNA methylation undergoes dynamic changes during development and cell differentiation.
Recent genome-wide studies discovered that tissue-specific differentially methylated …

DNA methylation is crucial for normal development and cellular differentiation in many large-
genome eukaryotes. The small tropical freshwater fish Danio rerio (zebrafish) has recently …

Genome-wide profiling of DNA methylation and histone modifications answered many
questions as to how the genes are regulated on a global scale and what their epigenetic …

DNA methylation on cytosine in vertebrates such as zebrafish serves to silence gene
expression by interfering with the binding of certain transcription factors and through the …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …