DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences
SJ Diede, J Guenthoer, LN Geng… - Proceedings of the …, 2010 - National Acad Sciences
DNA methylation might have a significant role in preventing normal differentiation in
pediatric cancers. We used a genomewide method for detecting regions of CpG methylation …
pediatric cancers. We used a genomewide method for detecting regions of CpG methylation …
Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas
JI Pritchard, JM Olson - Cancer genetics and cytogenetics, 2008 - Elsevier
The Sonic hedgehog (Shh) pathway is aberrantly activated in a subset of the most common
malignant pediatric brain tumor, medulloblastoma (MB). Shh pathway activity is measured …
malignant pediatric brain tumor, medulloblastoma (MB). Shh pathway activity is measured …
Aberrant promoter methylation of previously unidentified target genes is a common abnormality in medulloblastomas–implications for tumor biology and potential …
MC Frühwald, MS O'Dorisio, Z Dai, SM Tanner… - Oncogene, 2001 - nature.com
Medulloblastomas exhibit an array of diverse cytogenetic abnormalities. To evaluate the
significance of epigenetic rather than genetic lesions in medulloblastomas and other …
significance of epigenetic rather than genetic lesions in medulloblastomas and other …
Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer
Genetic and epigenetic alterations are essential for the initiation and progression of human
cancer. We previously reported that primary human medulloblastomas showed extensive …
cancer. We previously reported that primary human medulloblastomas showed extensive …
Array-based profiling of reference-independent methylation status (aPRIMES) identifies frequent promoter methylation and consecutive downregulation of ZIC2 in …
S Pfister, C Schlaeger, F Mendrzyk… - Nucleic acids …, 2007 - academic.oup.com
Existing microarray-based approaches for screening of DNA methylation are hampered by a
number of shortcomings, such as the introduction of bias by DNA copy-number imbalances …
number of shortcomings, such as the introduction of bias by DNA copy-number imbalances …
Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma tumors
Neuroblastoma is a very heterogeneous tumor of childhood. The clinical spectra range from
very aggressive metastatic disease to spontaneous regression, even without therapy …
very aggressive metastatic disease to spontaneous regression, even without therapy …
Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing
Epigenetic alterations, that is, disruption of DNA methylation and chromatin architecture, are
now acknowledged as a universal feature of tumorigenesis. Medulloblastoma, a clinically …
now acknowledged as a universal feature of tumorigenesis. Medulloblastoma, a clinically …
DNA methylation as a diagnostic tool
K Galbraith, M Snuderl - Acta Neuropathologica Communications, 2022 - Springer
DNA methylation of cytosines in CpG sites throughout the genome is an epigenetic mark
contributing to gene expression regulation. DNA methylation patterns are specific to tissue …
contributing to gene expression regulation. DNA methylation patterns are specific to tissue …
[HTML][HTML] Characterization of DNA methylation and its association with other biological systems in lymphoblastoid cell lines
Z Zhang, J Liu, M Kaur, ID Krantz - Genomics, 2012 - Elsevier
Lymphoblastoid cell line (LCL) is a common tool to study genetic disorders. However, it has
not been fully characterized to what degree LCLs preserve the in vivo status of non-genetic …
not been fully characterized to what degree LCLs preserve the in vivo status of non-genetic …
Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells
I Hatada, S Morita, M Kimura, T Horii… - Journal of human …, 2008 - nature.com
Epigenetic regulation including DNA methylation plays an important role in several
differentiation processes. We profiled global DNA methylation in the neural differentiation of …
differentiation processes. We profiled global DNA methylation in the neural differentiation of …
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