Janet C. Lindsey· Ed. C. Schwalbe· Sandeep Potluri· Simon Bailey· Daniel Williamson·
Steven C. Clifford received: 2 November 2013/revised: 28 November 2013/Accepted: 29 …

Alterations in DNA methylation (DNAm) in cancer have been known for 25 years, including
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …

Rapid and reliable detection of disease-associated DNA methylation patterns has major
potential to advance molecular diagnostics and underpin research investigations. We …

Candidate gene investigations have indicated a significant role for epigenetic events in the
pathogenesis of medulloblastoma, the most common malignant brain tumor of childhood. To …

Background Gliomas are the most common type of primary brain tumor and one of many
cancers where males are diagnosed with greater frequency than females. However, little is …

Recent advances in genomic technologies have allowed for tremendous progress in our
understanding of the biology underlying medulloblastoma, a malignant childhood brain …

Cytosine-5 DNA methylation occurs in the context of CpG dinucleotides in vertebrates.
Aberrant methylation of CpG islands in human tumors has been shown to cause …

Epigenetic modifications and particularly the methylation of cytosines 5′ of guanine
residues (CpGs) in gene promoter regions is an essential regulatory mechanism for normal …

DNA methylation is essential for normal development,, and has been implicated in many
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …

DNA methylation loss occurs frequently in cancer genomes, primarily within lamina-
associated, late-replicating regions termed partially methylated domains (PMDs). We …