Promoter hypermethylation represents a primary mechanism in the inactivation of tumor
suppressor genes during tumorigenesis. To determine the frequency and timing of …

Glioblastoma multiforme (GBM) is the most aggressive of all brain tumors, with a median
survival of less than 1.5 years. Recently, epigenetic alterations were found to play key roles …

DNA methylation is essential for normal development,, and has been implicated in many
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …

The extent and role of aberrant DNA methylation in promoter CpG islands (CGIs) have been
extensively studied in leukemia and other malignancies. Still, CGIs represent only a small …

For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur
in cancer, including hypomethylation of oncogenes and hypermethylation of tumor …

DNA methylation is an epigenetic change to the genome that impacts gene activities without
modification to the DNA sequence. Alteration in the methylation pattern is a naturally …

DNA methylation is an epigenetic modification involved in both normal developmental
processes and disease states through the modulation of gene expression and the …

BACKGROUND Osteosarcoma is the most common solid malignant diseases of childhood,
occurring in approximately 6 children per million annually; however, to the authors' …

The discovery of cancer-associated alterations has primarily focused on genetic variants.
Nonetheless, altered epigenomes contribute to deregulate transcription and promote …

Neuroblastoma, one of the most common pediatric solid tumors, is characterized by two
extreme disease courses, spontaneous regression and life-threatening progression. Here …