The discovery of cancer-associated alterations has primarily focused on genetic variants.
Nonetheless, altered epigenomes contribute to deregulate transcription and promote …

Background Grade IV glioblastomas exist in two forms, primary (de novo) glioblastomas
(pGBM) that arise without precursor lesions, and the less common secondary glioblastomas …

Differentiation of embryonic stem (ES) cells into embryoid bodies (EBs) provides an in vitro
system for the study of early lineage determination during mammalian development. We …

Background In this study we aimed to quantify tumor suppressor gene (TSG) promoter
methylation densities levels in primary neuroblastoma tumors and cell lines. A subset of …

The downregulation of specific genes through DNA hypermethylation is a major hallmark of
cancer, although the extent and genomic distribution of hypermethylation occurring within …

Epigenetic alterations are hallmarks of cancer and powerful biomarkers, whose clinical
utilization is made difficult by the absence of standardization and of common methods of …

DNA methylation has a role in the regulation of gene expression during normal mammalian
development but can also mediate epigenetic silencing of CpG island genes in cancer and …

Global changes in DNA methylation correlate with altered gene expression and genomic
instability in cancer. We have developed a methylation-specific digital sequencing (MSDS) …

During the last two decades, several international consortia have been established to unveil
the molecular background of human cancers including gliomas. As a result, a huge outbreak …

Epigenetic events like DNA methylation are known to regulate gene expression, and
dysregulation of these events is associated with neoplastic proliferation. Here, we provide a …