Almost all cancer cells have multiple epigenetic abnormalities, which combine with genetic
changes to affect many cellular processes, including cell proliferation and invasion, by …

Cytosine methylation is a DNA modification generally associated with transcriptional
silencing. Factors that regulate methylation have been linked to human disease, yet how …

DNA methylation is a heritable modification of genomic DNA central to development,
imprinting, transcriptional regulation, chromatin structure, and overall genomic stability …

Background Abnormal DNA methylation may be important in germ cell tumour (GCT)
aetiology, as germ cells undergo complete epigenetic reprogramming during development …

DNA methylation, a DNA modification by adding methyl group to cytosine, has an important
role in the regulation of gene expression. DNA methylation is known to be associated with …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …

DNA methylation plays an important role in regulating normal development and
carcinogenesis. Current understanding of the biological roles of DNA methylation is limited …

Background There is growing evidence that DNA methylation alterations contribute to
carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the …

ABSTRACT DNA methylation can affect tissue-specific gene transcription in ways that are
difficult to discern from studies focused on genome-wide analyses of differentially …

A unique microarray-based method for determining the extent of DNA methylation has been
developed. It relies on a selective enrichment of the regions to be assayed by target …