A practical guide to the measurement and analysis of DNA methylation
BD Singer - American journal of respiratory cell and molecular …, 2019 - atsjournals.org
DNA methylation represents a fundamental epigenetic mark that is associated with
transcriptional repression during development, maintenance of homeostasis, and disease …
transcriptional repression during development, maintenance of homeostasis, and disease …
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm
DNA methylation plays key roles in diverse biological processes such as X chromosome
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
Genome-scale DNA methylation analysis
SD Fouse, RP Nagarajan, JF Costello - Epigenomics, 2010 - Future Medicine
The haploid human genome contains approximately 29 million CpGs that exist in a
methylated, hydroxymethylated or unmethylated state, collectively referred to as the DNA …
methylated, hydroxymethylated or unmethylated state, collectively referred to as the DNA …
[HTML][HTML] methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles
DNA methylation is a chemical modification of cytosine bases that is pivotal for gene
regulation, cellular specification and cancer development. Here, we describe an R package …
regulation, cellular specification and cancer development. Here, we describe an R package …
[HTML][HTML] DMRfinder: efficiently identifying differentially methylated regions from MethylC-seq data
JM Gaspar, RP Hart - BMC bioinformatics, 2017 - Springer
Background DNA methylation is an epigenetic modification that is studied at a single-base
resolution with bisulfite treatment followed by high-throughput sequencing. After alignment …
resolution with bisulfite treatment followed by high-throughput sequencing. After alignment …
Methods in DNA methylation profiling
Metastable and somatically heritable patterns of DNA methylation provide an important level
of genomic regulation. In this article, we review methods for analyzing these genome-wide …
of genomic regulation. In this article, we review methods for analyzing these genome-wide …
Whole genome DNA methylation analysis based on high throughput sequencing technology
N Li, M Ye, Y Li, Z Yan, LM Butcher, J Sun, X Han… - Methods, 2010 - Elsevier
There are numerous approaches to decipher a whole genome DNA methylation profile
(“methylome”), each varying in cost, throughput and resolution. The gold standard of these …
(“methylome”), each varying in cost, throughput and resolution. The gold standard of these …
The DNA methylation landscape in cancer
As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …
plays an essential role in normal development and cellular biology. Global alterations to the …
Accurate quantification of DNA methylation using combined bisulfite restriction analysis coupled with the Agilent 2100 Bioanalyzer platform
RM Brena, H Auer, K Kornacker… - Nucleic acids …, 2006 - academic.oup.com
DNA methylation is the best-studied epigenetic modification and describes the conversion of
cytosine to 5-methylcytosine. The importance of this phenomenon is that aberrant promoter …
cytosine to 5-methylcytosine. The importance of this phenomenon is that aberrant promoter …
Enhanced reduced representation bisulfite sequencing for assessment of DNA methylation at base pair resolution
FE Garrett-Bakelman, CK Sheridan… - JoVE (Journal of …, 2015 - jove.com
DNA methylation pattern mapping is heavily studied in normal and diseased tissues. A
variety of methods have been established to interrogate the cytosine methylation patterns in …
variety of methods have been established to interrogate the cytosine methylation patterns in …