DNA methylation is one of the epigenetic changes, which plays a major role in regulating
gene expression and, thus, many biological processes and diseases. There are several …

The combination of DNA bisulfite treatment with high-throughput sequencing technologies
has enabled investigation of genome-wide DNA methylation at near base pair level …

Background The growing interest in the role of epigenetic modifications in human health and
disease has led to the development of next-generation sequencing methods for whole …

In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …

One of the most challenging projects in the field of epigenetics is the generation of detailed
functional maps of DNA methylation in different cell and tissue types in normal and disease …

EpiTYPER® is a mass spectrometry-based bisulfite sequencing method that enables region-
specific DNA methylation analysis in a quantitative and high-throughput fashion. The …

Sequencing technologies have changed not only our approaches to classical genetics, but
also the field of epigenetics. Specific methods allow scientists to identify novel genome-wide …

DNA methylation is an epigenetic modification involved in both normal developmental
processes and disease states through the modulation of gene expression and the …

As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …

Bisulfite sequencing is a powerful technique to detect 5-methylcytosine in DNA that has
immensely contributed to our understanding of epigenetic regulation in plants and animals …