Sequencing-based approaches have led to new insights about DNA methylation. While
many different techniques for genome-scale mapping of DNA methylation have been …

DNA methylation based biomarkers have considerable potential for molecular diagnostics,
both as tumor specific biomarkers for the early detection or post-therapeutic monitoring of …

We have recently shown that transcription factor binding leads to defined reduction in DNA
methylation, allowing for the identification of active regulatory regions from high-resolution …

Methylation of CpG dinucleotides plays a crucial role in the regulation of gene expression
and therefore in the development of different pathologies. Aberrant methylation has been …

DNA methylation patterns are altered in numerous diseases and often correlate with
clinically relevant information such as disease subtypes, prognosis and drug response. With …

MethylCap-seq is a robust procedure for genome-wide profiling of DNA methylation. The
approach consists of the capture of methylated DNA using the MBD domain of MeCP2, and …

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine.
To understand the biological significance of this epigenetic mark it is essential to know …

Methylation of cytosines (mC) is essential for epigenetic gene regulation in plants and
mammals. Aberrant mC patterns are associated with heritable developmental abnormalities …

Cytosine-5 RNA methylation plays an important role in several biologically and
pathologically relevant processes. However, owing to methodological limitations, the …

DNA methylation contributes to the control of gene expression and plays an essential role in
cellular physiology. Well-defined patterns of DNA methylation are established and fixed …