DNA methylation has been implicated in mammalian development. Transcription units
contain CpG islands, but expression of CpG island associated genes in normal tissues was …

Early studies proposed that DNA methylation could have a role in regulating gene
expression during development [Riggs, AD (1975) Cytogenet. Cell Genet. 14, 9–25] …

Differentiation of embryonic stem (ES) cells into embryoid bodies (EBs) provides an in vitro
system for the study of early lineage determination during mammalian development. We …

DNA methylation is a conspicuous feature of vertebrate genomes. Approximately 4% of total
cytosines are methylated, representing about 5× 10 7 5-methylcytosine (5-mC) residues per …

CpG islands are normally methylation free in cells of the animal, even when the associated
gene is transcriptionally silent. In mouse NIH 3T3 and L cells, however, over half of the …

The human genome contains∼ 30,000 CpG islands (CGIs). While CGIs associated with
promoters nearly always remain unmethylated, many of the∼ 9,000 CGIs lying within gene …

Background: DNA methylation is involved in many gene functions such as gene‐silencing, X‐
inactivation, imprinting and stability of the gene. We recently found that some CpG islands …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …

DNA methylation plays a role in the repression of gene expression in animal cells. In the
mouse preimplantation embryo, most genes are unmethylated but a wave of de novo …

The methylation of CpG islands is often equated with transcriptional inactivity and there is
overwhelming evidence that this is the case for islands located in gene promoters. Such …