Abstract Changes in DNA methylation patterns during embryo development and
differentiation processes are linked to the transcriptional plasticity of our genome. However …

In vertebrates, methylation of cytosine at CpG sequences is implicated in stable and
heritable patterns of gene expression. The classical model for inheritance, in which …

Most investigations on the role of DNA methylation in cancer have focused on epigenetic
changes associated with known tumor suppressor genes. This may have led to an …

Abstract We applied Illumina Human Methylation450K array to perform a genomic-scale
single-site resolution DNA methylation analysis in neuronal and nonneuronal (primarily …

CpG DNA methylation has previously been correlated with the suppression of transcription.
The mechanism of this suppression is not understood, and many aspects of the temporal …

A large number of studies have documented the methylation patterns of individual genes
and repeated sequences in different tissues of various mammalian species. This has …

We characterized the DNA methylation status at 144 tissue-biased and 37 non-tissue-biased
alternative promoters of 61 human genes in five normal tissues. Analysis of the collected …

Unmethylated CpG rich islands are a feature of vertebrate DNA: they are associated with
housekeeping and many tissue specific genes. CpG islands on the active X chromosome of …

Precise mapping of DNA methylation patterns in CpG islands has become essential for
understanding diverse biological processes such as the regulation of imprinted genes, X …

CpG islands (CGIs) are dense clusters of CpG sequences that punctuate the CpG-deficient
human genome and associate with many gene promoters. As CGIs also differ from bulk …