The de novo methylation activity of Dnmt3a is distinctly different than that of Dnmt1
CL Hsieh - BMC biochemistry, 2005 - Springer
Abstract Background Though Dnmt1 is considered the primary maintenance
methyltransferase and Dnmt3a and Dnmt3b are considered de novo methyltransferases in …
methyltransferase and Dnmt3a and Dnmt3b are considered de novo methyltransferases in …
Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L
MS Kareta, ZM Botello, JJ Ennis, C Chou… - Journal of Biological …, 2006 - ASBMB
The DNMT3-like protein, DNMT3L, is required for germ line DNA methylation, although it is
inactive as a DNA methyltransferase per se. Previous studies have shown that DNMT3L …
inactive as a DNA methyltransferase per se. Previous studies have shown that DNMT3L …
DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction
I Suetake, F Shinozaki, J Miyagawa… - Journal of Biological …, 2004 - ASBMB
In mammals, the resetting of DNA methylation patterns in early embryos and germ cells is
crucial for development. Two DNA methyltransferases, Dnmt3a and Dnmt3b, are …
crucial for development. Two DNA methyltransferases, Dnmt3a and Dnmt3b, are …
Interactions within the mammalian DNA methyltransferase family
JB Margot, AE Ehrenhofer-Murray, H Leonhardt - BMC molecular biology, 2003 - Springer
Background In mammals, epigenetic information is established and maintained via the
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …
Preferential methylation of unmethylated DNA by mammalian de novo DNA methyltransferase Dnmt3a
T Yokochi, KD Robertson - Journal of Biological Chemistry, 2002 - ASBMB
DNA methylation is an epigenetic modification of DNA. There are currently three catalytically
active mammalian DNA methyltransferases, DNMT1,-3a, and-3b. DNMT1 has been shown …
active mammalian DNA methyltransferases, DNMT1,-3a, and-3b. DNMT1 has been shown …
A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA
Dnmt3a and Dnmt3b are paralogous enzymes responsible for de novo DNA methylation but
with distinguished biological functions. In mice, disruption of Dnmt3b but not Dnmt3a causes …
with distinguished biological functions. In mice, disruption of Dnmt3b but not Dnmt3a causes …
Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival
G Egger, S Jeong, SG Escobar… - Proceedings of the …, 2006 - National Acad Sciences
Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for
maintenance of bulk DNA methylation and is essential for mouse development. However …
maintenance of bulk DNA methylation and is essential for mouse development. However …
Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA
M Fatemi, A Hermann, H Gowher… - European journal of …, 2002 - Wiley Online Library
Dnmt3a is a de novo DNA methyltransferase that modifies unmethylated DNA. In contrast
Dnmt1 shows high preference for hemimethylated DNA. However, Dnmt1 can be activated …
Dnmt1 shows high preference for hemimethylated DNA. However, Dnmt1 can be activated …
Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non …
We present the first in vitro study investigating the catalytic properties of a mammalian de
novo DNA methyltransferase. Dnmt3a from mouse was cloned and expressed in …
novo DNA methyltransferase. Dnmt3a from mouse was cloned and expressed in …
Domain structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA methyltransferases
In mammals, three major DNA methyltransferases, Dnmt1, Dnmt3a, and Dnmt3b, have been
identified. Dnmt3a and Dnmt3b are responsible for establishing DNA methylation patterns …
identified. Dnmt3a and Dnmt3b are responsible for establishing DNA methylation patterns …