The placenta acts not only as a conduit of nutrient and waste exchange between mother and
developing fetus, but also functions as a regulator of the intrauterine environment. Recent …

Throughout in utero development, the placenta plays a key role in controlling growth and
development. The placenta acts not only as a gatekeeper of nutrient and waste exchange …

Epigenetic processes, such as DNA methylation, are known to regulate tissue specific gene
expression. We explored this concept in the placenta to define whether DNA methylation is …

This review provides an overview of the unique features of DNA methylation in the human
placenta. We discuss the importance of understanding placental development, structure …

The placenta, which plays a critical structural and functional role during pregnancy, is a key
link in the chain of events that lead to intrauterine programming of adult health. Placental …

Epigenetic modifications, and particularly DNA methylation, have been studied in many
tissues, both healthy and diseased, and across numerous developmental stages. The …

Fetal growth is determined by the feto-placental genome interacting with the maternal in
utero environment. Failure of this interplay leads to poor placental development and fetal …

Critical roles for DNA methylation in embryonic development are well established, but less is
known about its roles during trophoblast development, the extraembryonic lineage that gives …

Over the last 20-80 million years the mammalian placenta has taken on a variety of
morphologies through both divergent and convergent evolution. Recently we have shown …

Infants undergo extensive developments during their first year of life. Although the biological
mechanisms involved are not yet fully understood, changes in the DNA methylation in …