Pathways that control and modulate DNA methylation patterning in mammalian cells were
poorly understood for a long time, although their importance in establishing and maintaining …

Cell type-specific DNA methylation patterns are established during mammalian
development and maintained in adult somatic cells. Understanding how these patterns of 5 …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

DNA methylation on cytosine is an epigenetic modification and is essential for gene
regulation and genome stability in vertebrates. Traditionally DNA methylation was …

DNA methylation and demethylation are increasingly recognized as important epigenetic
factors in both plants and animals. DNA methylation, which is catalyzed by DNA …

DNA methylation is one of the best-characterized epigenetic modifications and has been
implicated in numerous biological processes, including transposable element silencing …

Variability and adaptability are necessary for overcoming the challenges of multicellular life.
To address this need, nature has evolved a substantial enzymatic toolbox for altering …

From a fertilised egg to a mature organism, cells divide and accumulate epigenetic
information, which is faithfully passed on to daughter cells. DNA methylation consolidates …

Mammalian DNA methyltransferases (DNMTs) establish and maintain genomic DNA
methylation patterns that are required for proper epigenetic regulation of gene expression …

DNA cytosine methylation is a reversible epigenetic mark regulating gene expression.
Aberrant methylation profiles are concomitant with developmental defects and cancer …