Remodelling the methylome is a hallmark of mammalian development and cell
differentiation. However, current knowledge of DNA methylation dynamics in human tissue …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

Background Changes in DNA methylation in the mammalian genome during development
are frequent events and play major roles regulating gene expression and other …

Cytosine DNA methylation is essential for mammalian development but understanding of its
spatiotemporal distribution in the developing embryo remains limited,. Here, as part of the …

The question of whether DNA methylation contributes to the stabilization of gene expression
patterns in differentiated mammalian tissues remains controversial. Using genome-wide …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …

DNA methylation is an important epigenetic modification involved in many biological
processes and diseases. Many studies have mapped DNA methylation changes associated …

DNA methylation is a fundamental epigenetic mark that governs chromatin organization, cell
identity, and gene expression. Here we describe a human methylome atlas, based on deep …

Background Early life is a period of drastic epigenetic remodeling in which the epigenome is
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …

Background Uncovering mechanisms of epigenome evolution is an essential step towards
understanding the evolution of different cellular phenotypes. While studies have confirmed …