Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

DX Tan, R Hardeland - Melatonin Research, 2020 - melatonin-research.net
The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19,
and avian flu is often caused by the uncontrolled innate immune response and destructive …

Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID‐19

JL Reynolds, ML Dubocovich - Journal of pineal research, 2021 - Wiley Online Library
Data indicate that controlling inflammatory responses to COVID‐19 may be as important as
antiviral therapies or could be an important adjunctive approach. Melatonin possesses anti …

Low melatonin as a contributor to SARS-CoV-2 disease

SR Pandi Perumal, DP Cardinali, R Reiter, GM Brown - 2020 - repositorio.uca.edu.ar
That the pineal gland is a source of melatonin is widely known; however, by comparison, few
know of the much larger pool of extrapineal melatonin. That pool is widely distributed in all …

Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease

DM Chitimus, MR Popescu, SE Voiculescu… - Biomolecules, 2020 - mdpi.com
There is a growing consensus that the antioxidant and anti-inflammatory properties of
melatonin are of great importance in preserving the body functions and homeostasis, with …

Coronavirus disease 2019 (COVID-19) and its neuroinvasive capacity: Is it time for melatonin?

A Romero, E Ramos, F Lopez-Munoz… - Cellular and molecular …, 2022 - Springer
The world faces an exceptional new public health concern caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), subsequently termed the coronavirus …

Fluvoxamine, melatonin and COVID-19

GM Anderson - Psychopharmacology, 2021 - Springer
The recent report of Lenze and colleagues (Lenze et al. 2020) indicates that the selective
serotonin reuptake inhibitor (SSRI) fluvoxamine might reduce the rate of clinical …

Melatonin potentials against viral infections including COVID-19: Current evidence and new findings

KB Juybari, MH Pourhanifeh, A Hosseinzadeh… - Virus research, 2020 - Elsevier
Viral infections are dangerous diseases for human health worldwide, which lead to
significant morbidity and mortality each year. Because of their importance and the lack of …

Evaluation of the efficacy and safety of Melatonin in moderately ill patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial

A Ziaei, P Davoodian, H Dadvand, O Safa… - Trials, 2020 - Springer
Objectives We will evaluate the efficacy and safety of Melatonin, compared to the standard
therapeutic regimen on clinical symptoms and serum inflammatory parameters in patients …

[HTML][HTML] Melatonin use for SARS‐CoV‐2 infection: Time to diversify the treatment portfolio

RJ Reiter, R Sharma, DX Tan, RL Neel… - Journal of Medical …, 2022 - ncbi.nlm.nih.gov
To the Editor, We were pleased to read the publication by Lan et al. 1 which included a meta‐
analysis of the randomized controlled trials (RCTs) in which melatonin was used as a …

The safety and efficacy of melatonin in the treatment of COVID-19: A systematic review and meta-analysis

XC Wang, GL Wu, YF Cai, SJ Zhang - Medicine, 2022 - journals.lww.com
Background: As an infectious disease caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the common signs of coronavirus disease 2019 (COVID-19) …