[HTML][HTML] Melatonin, zinc, and vitamin C: Potential adjuvant treatment for COVID-19 patients

L Borges, M Gennari-Felipe, BB Dias… - Frontiers in …, 2022 - frontiersin.org
The use of nutraceutical approaches may regulate the immune system, performing a
potential strategy to contain the worst outcomes of COVID-19. We reviewed the current …

[HTML][HTML] Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels

E Cecon, D Fernandois, N Renault, CFF Coelho… - Cellular and Molecular …, 2022 - Springer
COVID-19 is a complex disease with short-and long-term respiratory, inflammatory and
neurological symptoms that are triggered by the infection with SARS-CoV-2. Invasion of the …

[HTML][HTML] Endoplasmic reticulum stress in elderly patients with COVID-19: potential of melatonin treatment

GT Yiang, CC Wu, CL Lu, WC Hu, YJ Tsai, YM Huang… - Viruses, 2023 - mdpi.com
Aging processes, including immunosenescence, inflammation, inflammasome formation,
genomic instability, telomeric attrition, and altered autophagy, are involved in viral infections …

A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 …

M Rodríguez Rubio, D Acuña Castroviejo… - 2020 - digibug.ugr.es
Objectives:• Primary objective: to evaluate the effect of intravenous melatonin (IVM) on
mortality in adult patients admitted to the intensive care unit (ICU) with COVID-19.• …

A pilot of a randomized control trial of melatonin and vitamin C for mild-to-moderate COVID-19

C Fogleman, D Cohen, A Mercier… - The Journal of the …, 2022 - Am Board Family Med
This study aimed to help determine the effect of dietary supplements on symptom course
and quality of life in patients with mild-to-moderate COVID-19 infection. Design: We modified …

Possible role of tryptophan and melatonin in COVID-19

MM Essa, H Hamdan… - International …, 2020 - journals.sagepub.com
1Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat,
Oman. 2Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman …

Melatonin interferes with COVID-19 at several distinct ROS-related steps

OG Camp, D Bai, DC Gonullu, N Nayak… - Journal of Inorganic …, 2021 - Elsevier
Recent studies have shown a correlation between COVID-19, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and the distinct, exaggerated …

[HTML][HTML] High dose melatonin as an adjuvant therapy in intubated patients with COVID-19: A randomized clinical trial

N Alizadeh, M Dianatkhah, Y Alimohamadi… - Journal of Taibah …, 2022 - Elsevier
Objective In the COVID-19 pandemic, the SARS-CoV-2 virus has infected millions of people
worldwide. Mortality primarily results from the inflammation state and its complications. High …

Autism spectrum disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin

GM Brown, R Karthikeyan, SR Pandi-Perumal… - Medical hypotheses, 2021 - Elsevier
Abstract Patients with Autism Spectrum Disorder (ASD) may be particularly prone to develop
COVID-19. An unusual extended course of COVID-19 disease illness has been reported in …

A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A …

IG García, M Rodriguez-Rubio, AR Mariblanca… - Trials, 2020 - Springer
Objectives Primary objective: to evaluate the efficacy of melatonin as a prophylactic
treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at …