Charting a dynamic DNA methylation landscape of the human genome
DNA methylation is a defining feature of mammalian cellular identity and is essential for
normal development,. Most cell types, except germ cells and pre-implantation embryos …
normal development,. Most cell types, except germ cells and pre-implantation embryos …
Spatiotemporal DNA methylome dynamics of the developing mouse fetus
Cytosine DNA methylation is essential for mammalian development but understanding of its
spatiotemporal distribution in the developing embryo remains limited,. Here, as part of the …
spatiotemporal distribution in the developing embryo remains limited,. Here, as part of the …
Genome-scale DNA methylation maps of pluripotent and differentiated cells
DNA methylation is essential for normal development,, and has been implicated in many
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …
Human body epigenome maps reveal noncanonical DNA methylation variation
Understanding the diversity of human tissues is fundamental to disease and requires linking
genetic information, which is identical in most of an individual's cells, with epigenetic …
genetic information, which is identical in most of an individual's cells, with epigenetic …
A DNA methylation atlas of normal human cell types
DNA methylation is a fundamental epigenetic mark that governs gene expression and
chromatin organization, thus providing a window into cellular identity and developmental …
chromatin organization, thus providing a window into cellular identity and developmental …
Human DNA methylomes at base resolution show widespread epigenomic differences
DNA cytosine methylation is a central epigenetic modification that has essential roles in
cellular processes including genome regulation, development and disease. Here we …
cellular processes including genome regulation, development and disease. Here we …
The DNA methylation landscape of human early embryos
H Guo, P Zhu, L Yan, R Li, B Hu, Y Lian, J Yan, X Ren… - Nature, 2014 - nature.com
DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …
DNA methylation dynamics of the human preimplantation embryo
In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and
stably distributed across the genome, with local, cell-type-specific regulation directed by …
stably distributed across the genome, with local, cell-type-specific regulation directed by …
DNA methylation profiling of human chromosomes 6, 20 and 22
F Eckhardt, J Lewin, R Cortese, VK Rakyan, J Attwood… - Nature …, 2006 - nature.com
DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …
on gene expression, we measured methylation, RNA polymerase occupancy and histone …