The total genomic DNA methylation, ie, the percentage of methylated cytosines, was
measured in 20 cell lines derived from different types of human tumors. The measurements …

The status of DNA methylatlon, as measured by the 5-methylcytosine content of nuclear
DNA, was examined in normal livers and in chemically induced or spontaneous primary …

Publisher Summary This chapter discusses the role of DNA methylation in carcinogenesis
and tumor diversification. The methylation of HpaII and Hha1 sites in DNA isolated from the …

The main thrusts of the arguments that aberrant DNA methylation is involved in the
generation of tumor heterogeneity and progression can be summarized as follows. The …

DNA methylation appears to play an important role in both physiological and experimentally
modified gene expression, and alterations in DNA methylation have been described in …

Changes in the pattern of DNA methylation have been a consistent finding in cancer cells.
The mostly descriptive nature of these studies and the fact that both hypo-and …

Site-specific methylation of the human c-myc oncogene was investigated in a set of cultured
human tumor cell lines and normal human fibroblast strains. As previously reported, all of …

It has been suggested that cancer represents an alteration in DNA, heritable by progeny
cells, that leads to abnormally regulated expression of normal cellular genes; DNA …

The global DNA methylation status was investigated on a series of 59 breast cancers by
Southern blotting, using methylation sensitive restriction enzymes. By comparison to control …

In contrast to earlier views that there was much compartmentalization of the types of
sequences subject to cancer-linked changes in DNA epigenetics, it is now clear that both …