DNA methylation constitutes an important epigenetic regulation mechanism in many
eukaryotes, although the extent of DNA methylation in the regulation of gene expression in …

Background DNA methylation plays an important role in regulating gene expression during
many biological processes. However, the mechanism of DNA-methylation-dependent gene …

We report a novel resource (m ethylation p rofiles of D NA, or mPod) for human genome-
wide tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts …

Background Changes in DNA methylation in the mammalian genome during development
are frequent events and play major roles regulating gene expression and other …

The modification of DNA by methylation is an important epigenetic mechanism that affects
the spatial and temporal regulation of gene expression. Methylation patterns have been …

Background Many groups, including our own, have proposed the use of DNA methylation
profiles as biomarkers for various disease states. While much research has been done …

Background DNA epigenetic modifications, such as methylation, are important regulators of
tissue differentiation, contributing to processes of both development and cancer. Profiling the …

DNA methylation is crucial for gene regulation and maintenance of genomic stability. Rat
has been a key model system in understanding mammalian systemic physiology, however …

Early studies proposed that DNA methylation could have a role in regulating gene
expression during development [Riggs, AD (1975) Cytogenet. Cell Genet. 14, 9–25] …

Tissue specific differentially methylated regions (TDMRs) were identified and localized in the
mouse genome using second generation virtual RLGS (vRLGS). Sequenom MassARRAY …