To explain why solid cancers grow or are rejected, we examined how the tumor stroma
affected the level of antigen expression necessary to induce an immune response. We …

Targeting cancer cells, as well as the nonmalignant stromal cells cross-presenting the tumor
antigen (Ag), can lead to the complete destruction of well-established solid tumors by …

The growth of solid tumors depends on tumor stroma. A single adoptive transfer of CD8+
CTLs that recognize tumor antigen–loaded stromal cells, but not the cancer cells because of …

Cancers frequently evade cytotoxic T lymphocyte–mediated destruction through loss or
down-regulation of tumor antigens and antigen-presenting major histocompatibility complex …

The immune system of cancer patients recognizes tumor-associated antigens expressed on
solid tumors and these antigens are able to induce tumor-specific humoral and cellular …

A single tumor contains a heterogeneous population of cancer cells. Some cancer cells
express antigens and are susceptible to specific CTLs. However, other cancer cells are …

A better understanding of how solid malignancies arise in an immunocompetent host, avoid
immune recognition, and ultimately progress to widely disseminated cancer is essential to …

Purpose: The propensity of tumor cells to escape immune elimination could limit, if not
defeat, the long-term benefits of effective immunotherapeutic protocols. Immunologic …

Two seemingly incompatible models exist to explain the progression of cancers in
immunocompetent hosts. The cancer immunosurveillance hypothesis posits that recognition …

Maximizing the potential of cancer immunotherapy requires model systems that closely
recapitulate human disease to study T-cell responses to tumor antigens and to test …