Mindfulness Based Stress Reduction (MBSR) is an effective non-pharmacologic treatment
for veterans with PTSD. Extensive work has identified epigenetic factors related to PTSD …

Objective: Understandings of the biological mechanisms underpinning posttrauma
responses are limited. This pilot study aimed to expand research in this area by examining …

Background Studies in adult depressed patients have indicated that altered DNA
methylation patterns at genes related to serotonin and HPA axis functioning (eg, SLC6A4 …

Epigenetic changes are currently invoked as explanations for both the chronicity and
tenacity of post-traumatic stress disorder (PTSD), a heterogeneous condition showing …

Abstract Background FK506-binding protein 5 (FKBP5) binds to glucocorticoid receptors and
modulates glucocorticoid sensitivity. The FKBP5 gene has been implicated in the …

Background Hypothalamic–pituitary–adrenal (HPA) axis functioning has been implicated in
the development of stress‐related psychiatric diagnoses and response to adverse life …

Background Previous research has demonstrated that epigenetic changes in specific
hypothalamic-pituitary-adrenal (HPA) genes may predict successful psychotherapy in post …

Background: Posttraumatic stress disorder (PTSD) is a common and debilitating mental
disorder that occurs following exposure to a traumatic event. However, most individuals do …

Epigenetic alterations offer promise as diagnostic or prognostic markers, but it is not known
whether these measures associate with, or predict, clinical state. These questions were …

Background We have previously evaluated the efficacy of the CRF 1 receptor antagonist
GSK561679 in female PTSD patients. While GSK561679 was not superior to placebo …