DNA methyltransferases (DNMTs) are an evolutionarily conserved family of DNA
methylases, transferring a methyl group onto the fifth carbon of a cytosine residue. The …

DNA methyltransferases (DNMTs) are the key enzymes for genome methylation, which plays
an important role in epigenetically regulated gene expression and repression. Mouse …

Somatic heterozygous mutations of the DNA methyltransferase gene DNMT3A occur
frequently in acute myeloid leukemia and other hematological malignancies, with the …

DNA methylation is an epigenetic process involved in development, aging, and cancer.
Although the advent of new molecular techniques has enhanced our knowledge of how …

Aberrant hypermethylation of tumor suppressor genes plays an important role in the
development of many tumors. Recently identified new DNA methyltransferase (DNMT) …

The de novo DNA methyltransferases Dnmt3a and Dnmt3b are of crucial importance in
hematopoietic stem cells. Dnmt3b has recently been shown to play a role in genic …

DNA methyltransferase 3A (DNMT3A) is an enzyme involved in DNA methylation that is
frequently mutated in human hematologic malignancies. We have previously shown that …

DNA methylation is essential for development and in diverse biological processes. The DNA
methyltransferase Dnmt1 maintains parental cell methylation patterns on daughter DNA …

In mammals, DNA methyltransferases DNMT1 and DNMT3's (A, B and L) deposit and
maintain DNA methylation in dividing and nondividing cells. Although these enzymes have …

DNA methylation patterns are disrupted in various malignancies, suggesting a role in the
development of cancer, but genetic aberrations directly linking the DNA methylation …