[HTML][HTML] Biologico-clinical significance of DNMT3A variants expression in acute myeloid leukemia
N Lin, W Fu, C Zhao, B Li, X Yan, Y Li - Biochemical and biophysical …, 2017 - Elsevier
Abstract DNA methyltransferase 3A (DNMT3A) catalyzes de novo DNA methylation and
plays important roles in the pathogenesis of acute myeloid leukemia. However, the …
plays important roles in the pathogenesis of acute myeloid leukemia. However, the …
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers
DA Russler-Germain, DH Spencer, MA Young… - Cancer cell, 2014 - cell.com
Somatic mutations in DNMT3A, which encodes a de novo DNA methyltransferase, are found
in∼ 30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations are …
in∼ 30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations are …
Mammalian DNA methyltransferases: new discoveries and open questions
As part of the epigenetic network, DNA methylation is a major regulator of chromatin
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells
Y Tadokoro, H Ema, M Okano, E Li… - The Journal of …, 2007 - rupress.org
DNA methylation is an epigenetic modification essential for development. The DNA
methyltransferases Dnmt3a and Dnmt3b execute de novo DNA methylation in gastrulating …
methyltransferases Dnmt3a and Dnmt3b execute de novo DNA methylation in gastrulating …
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers
MS Kim, YR Kim, NJ Yoo, SH Lee - Apmis, 2013 - Wiley Online Library
DNMT3A, a DNA methyltransferase that functions for de novo methylation, is important in
development and many cellular processes related to tumorigenesis. Somatic mutations of …
development and many cellular processes related to tumorigenesis. Somatic mutations of …
Domain structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA methyltransferases
In mammals, three major DNA methyltransferases, Dnmt1, Dnmt3a, and Dnmt3b, have been
identified. Dnmt3a and Dnmt3b are responsible for establishing DNA methylation patterns …
identified. Dnmt3a and Dnmt3b are responsible for establishing DNA methylation patterns …
Oligomerization of DNMT3A controls the mechanism of de novo DNA methylation
C Holz-Schietinger, DM Matje, MF Harrison… - Journal of Biological …, 2011 - ASBMB
DNMT3A is one of two human de novo DNA methyltransferases essential for regulating
gene expression through cellular development and differentiation. Here we describe the …
gene expression through cellular development and differentiation. Here we describe the …
DNA methyltransferases: classification, functions and research progress
ZG Wang, JX Wu - Yi Chuan= Hereditas, 2009 - europepmc.org
DNA methylation is a postreplicative modification occurred in most prokaryotic and
eukaryotic genomes, which has a variety of important biological functions including …
eukaryotic genomes, which has a variety of important biological functions including …
Expression levels of DNA methyltransferase genes do not correlate with p15INK4B gene methylation in myelodysplastic syndromes
E Aoki, H Ohashi, T Uchida, T Murate, H Saito… - Leukemia, 2003 - nature.com
The notion that gene silencing after methylation of promoters of tumor suppresser genes
results in carcinogenesis is supported by many lines of evidence. Myelodysplastic syndrome …
results in carcinogenesis is supported by many lines of evidence. Myelodysplastic syndrome …
DNA methyltransferases: a novel target for prevention and therapy
Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …
agents, and the use of various therapeutic combinations, none of the available treatment …