Biochemistry and biology of mammalian DNA methyltransferases
DNA methylation is a stable but not irreversible epigenetic signal that silences gene
expression. It has a variety of important functions in mammals, including control of gene …
expression. It has a variety of important functions in mammals, including control of gene …
DNA methyltransferases and their roles in tumorigenesis
W Zhang, J Xu - Biomarker research, 2017 - Springer
DNA methylation plays an important role in gene expression, chromatin stability, and genetic
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …
Structural basis of DNMT1 and DNMT3A-mediated DNA methylation
DNA methylation, one of the major epigenetic mechanisms, plays critical roles in regulating
gene expression, genomic stability and cell lineage commitment. The establishment and …
gene expression, genomic stability and cell lineage commitment. The establishment and …
Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation
Abstract DNA methyltransferase DNMT3A is essential for establishment of mammalian DNA
methylation during development. The R882H DNMT3A is a hotspot mutation in acute …
methylation during development. The R882H DNMT3A is a hotspot mutation in acute …
DNA methyltransferases in cancer: biology, paradox, aberrations, and targeted therapy
J Zhang, C Yang, C Wu, W Cui, L Wang - Cancers, 2020 - mdpi.com
DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals,
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …
DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells
J Xu, YY Wang, YJ Dai, W Zhang… - Proceedings of the …, 2014 - National Acad Sciences
The gene encoding DNA methyltransferase 3A (DNMT3A) is mutated in∼ 20% of acute
myeloid leukemia cases, with Arg882 (R882) as the hotspot. Here, we addressed the …
myeloid leukemia cases, with Arg882 (R882) as the hotspot. Here, we addressed the …
De novo DNA methyltransferases: oncogenes, tumor suppressors, or both?
AF Fernandez, C Huidobro, MF Fraga - Trends in Genetics, 2012 - cell.com
Aberrant promoter DNA hypermethylation of tumor suppressor genes is a hallmark of
cancer. This alteration is largely dependent on the action of de novo DNA …
cancer. This alteration is largely dependent on the action of de novo DNA …
Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia
E Jost, Q Lin, CI Weidner, S Wilop, M Hoffmann… - Leukemia, 2014 - nature.com
Mutations in the genetic sequence of the DNA de novo methyltransferase DNMT3A (DNA
methyltransferase 3A) are found in many patients with acute myeloid leukemia (AML). They …
methyltransferase 3A) are found in many patients with acute myeloid leukemia (AML). They …
CpG island hypermethylation mediated by DNMT3A is a consequence of AML progression
DNMT3A mutations occur in∼ 25% of acute myeloid leukemia (AML) patients. The most
common mutation, DNMT3A R882H, has dominant negative activity that reduces DNA …
common mutation, DNMT3A R882H, has dominant negative activity that reduces DNA …
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
A Vasanthakumar, JB Lepore… - Blood, The Journal …, 2013 - ashpublications.org
The drivers of abnormal DNA methylation in human cancers include widespread aberrant
splicing of the DNMT3B gene, producing abnormal transcripts that encode truncated …
splicing of the DNMT3B gene, producing abnormal transcripts that encode truncated …