Gene function in cancer can be disrupted either through genetic alterations, which directly
mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene …

The phenotype of the cancerous cell may arise either from genetic alterations that disrupt
gene function through sequence modifications (mutations) or epigenetic events that may …

Heritable alterations of DNA that do not affect the base pair sequence itself but nevertheless
regulate the predetermined activity of genes are referred to as epigenetic. Epigenetic …

Cancer is an epigenetic disease at the same level that it can be considered a genetic
disease. In fact, epigenetic changes, particularly DNA methylation, are susceptible to …

The methylation of DNA is an epigenetic modification that can play an important role in the
control of gene expression in mammalian cells. The enzyme involved in this process is DNA …

There is compelling evidence to support the importance of DNA methylation alterations in
cancer development. Both losses and gains of DNA methylation are observed, thought to …

Aberrant DNA methylation is known as an important cause of human cancers, along with
mutations. Although aberrant methylation was initially speculated to be similar to mutations …

The discovery of global DNA hypomethylation events in human tumors in the early 1980s
and the identification of CpG island promoter hypermethylation of tumor suppressor genes in …

The epigenome, which is comprised of chromatin and its associated proteins and the
patterns of covalent modification of DNA by methylation, sets up and maintains gene …

DNA methylation is one of several epigenetic changes observed in cells. Aberrant
methylation of tumor suppressor genes, proto-oncogenes, and vital cell cycle genes has led …