Cancer cells are associated with global hypomethylation but with focal hypermethylation of
specific gene promoters organized as CpG island. DNA methyltransferases, DNMT1 and 3 …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

In summary, it is apparent that alterations in DNA methylation are a fundamental molecular
change associated with the neoplastic process and have important biologic implications for …

This paper examines the relationship between DNA mutagenic lesions, DNA methylation
and the involvement of these changes in the process of carcinogenesis. Many types of DNA …

The discovery of numerous hypermethylated promoters of tumour–suppressor genes, along
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …

Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Precise and deliberate observations on tumors stand true for decades, and then meet
mechanistic explanations. The presence of genetic alterations in tumors is now widely …

Tumorigenesis begins with the disregulated growth of an abnormal cell that has acquired
the ability to divide more rapidly than its normal counterparts (Nowell, PC (1976) Science …

DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …

The observation that cancer cells suffer profound alterations in the DNA methylation profile,
with functional consequences in the activity of key genes, together with the recognition that …