Changes in human DNA methylation patterns are an important feature of cancer
development and progression and a potential role in other conditions such as …

Epigenetics is the study of all mechanisms that regulate gene transcription and genome
stability that are maintained throughout the cell division, but do not include the DNA …

DNA methylation is one of epigenetic mechanisms regulating gene expression. The
methylation pattern is determined during embryogenesis and passed over to differentiating …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …

DNA methylation is a mechanism for changing the base sequence of DNA without altering
its coding function. As a heritable, yet reversible, epigenetic change, it has the potential of …

Alterations of DNA methylation can account for the histological heterogeneity, reflected in
the stepwise progression and complex biological characteristics of human cancers, that …

While specific genes are hypermethylated in the genome of cancer cells, overall
methylcytosine content is often decreased as a consequence of hypomethylation affecting …

DNA methylation is known to be abnormal in all forms of cancer, but it is not really
understood how this occurs and what is its role in tumorigenesis. In this review, we take a …

There is strong evidence that DNA methylation is not a neutral bystander in carcinogenesis,
but actively contributes to the process. Methylation of cytosine is known to promote mutation …

Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …