The development of genetic tools to alter DNA methylation has led to a deeper
understanding of the importance of DNA modification in the life strategies of different …

Understanding how developmental and functional complexity of organisms evolves is a
longstanding challenge in biology. Genetic mutation has long been thought to be the cause …

Patterns of DNA cytosine methylation are subject to mitotic inheritance in both plants and
vertebrates. Plants use 5-methylcytosine glycosylases and the base excision repair pathway …

Background DNA methylation is a crucial epigenetic modification, which is involved in many
biological processes, including gene expression regulation, embryonic development, cell …

Summary DNA methyltransferase-1 (DNMT1) has a higher specific activity on
hemimethylated DNA than on unmethylated DNA, but this preference is too small to explain …

Cytosine DNA methylation is the addition of a methyl group to the 5′ position of a cytosine,
which plays a crucial role in plant development and gene silencing. Genome-wide profiling …

Active DNA demethylation underlies key facets of reproduction in flowering plants and
mammals and serves a general genome housekeeping function in plants. A family of 5 …

DNA methylation is an important modification of DNA that plays a role in genome
management and in regulating gene expression during development. Methylation is carried …

DNA methylation is catalyzed by a family of conserved DNA methyltransferases and is
widespread among protists, plants, fungi and animals. It is however absent in some species …

Abstract RNA Directed DNA Methylation (RdDM) is a pathway that mediates de novo DNA
methylation, an evolutionary conserved chemical modification of cytosine bases, which …