Alzheimer's disease (AD) is a neurodegenerative disease driven in large part by
accumulated deposits in the brain of the amyloid precursor protein (APP) cleavage product …

Soluble amyloid precursor protein-alpha (sAPPα) is a regulator of neuronal and memory
mechanisms, while also having neurogenic and neuroprotective effects in the brain. As adult …

Soluble amyloid precursor protein α (sAPPα), a secreted proteolytic fragment of
nonamyloidogenic amyloid precursor protein (APP) processing, is known for numerous …

Secreted amyloid precursor protein-α (sAPPα) is a neuroprotective and neurotrophic protein
derived from the parent APP molecule. We have shown that sAPPα enhances long-term …

Secreted amyloid precursor protein-α (sAPPα) is a neurotrophic and neuroprotective
molecule which can enhance learning and synaptic plasticity. Aging is associated with …

Aim The amyloid precursor protein (APP) is endoproteolytically processed to generate either
the neurotoxic beta-amyloid peptide (Aβ) or the secreted ectodomain APP alpha (sAPPα) …

J. Neurochem.(2012) 122, 208–220. Abstract The amyloid precursor protein (APP) is
thought to be neuroprotective following traumatic brain injury (TBI), although definitive …

Amyloid precursor protein (APP) is a transmembrane protein expressed largely within the
central nervous system. Upon cleavage, it does not produce the toxic amyloid peptide (Aβ) …

Secreted amyloid precursor protein-α (sAPPα) levels are reduced during the pathogenesis
of Alzheimer's disease, but the significance of this for neural function is not well understood …

Alzheimer's disease (AD) may be caused by the abnormal processing of the amyloid
precursor protein (APP) and the accumulation of β-amyloid (Aβ). The amyloid precursor …