Background Schizophrenia (SCZ) is a chronic and severe mental illness with no cure so far.
Mendelian randomization (MR) is a genetic method widely used to explore etiologies of …

Schizophrenia (SZ) is a complex disorder resulting from both genetic and environmental
causes with a lifetime prevalence world-wide of 1%; however, there are no specific, sensitive …

Schizophrenia (SZ) is a debilitating brain disorder with a complex genetic architecture.
Genetic studies, especially recent genome-wide association studies (GWAS), have identified …

Schizophrenia is a serious mental disease with high heritability. To better understand the
genetic basis of schizophrenia, we conducted a large scale integrative analysis of genome …

Schizophrenia (SCZ) is a polygenic disease with a heritability approaching 80%. Over 100
SCZ-related loci have so far been identified by genome-wide association studies (GWAS) …

Unlike the typical analysis of single markers in genome-wide association studies (GWAS),
we incorporated Gene Set Enrichment Analysis (GSEA) and hypergeometric test and …

Background: Schizophrenia is a complex mental disorder. The genetic mechanism of
schizophrenia remains elusive now. Methods: We conducted a large-scale integrative …

ObjectiveGenetic approaches are increasingly advantageous in characterizing treatment-
resistant schizophrenia (TRS). We aimed to identify TRS-associated functional brain …

There is genetic evidence that schizophrenia is a polygenic disorder with a large number of
loci of small effect on disease susceptibility. Genome-wide association studies (GWASs) of …

Genome-wide association studies (GWAS) have identified abundant risk loci associated with
schizophrenia (SCZ), cardiometabolic disease (CMD) including body mass index, coronary …