Hypermethylation of CpG islands is a phenomenon commonly observed during the
development and progression of human tumors. Detection of methylated-CpG islands in …

Methylation of CpG islands is associated with transcriptional repression and, in cancer,
leads to the abnormal silencing of tumor suppressor genes. We have developed a novel …

Hypermethylation of CpG island (CGI) sequences is a nearly universal somatic genome
alteration in cancer. Rapid and sensitive detection of DNA hypermethylation would aid in …

DNA methylation patterns are often altered in human cancer and aberrant methylation is
considered a hallmark of malignant transformation. Several methods have been developed …

The methylated-CpG island recovery assay (MIRA) exploits the intrinsic specificity and the
high affinity of a methylated-CpG-binding protein complex (MBD2B and MBD3L1) to …

CpG island methylation has been linked to tumor suppressor gene inactivation in neoplasia
and may serve as a useful marker to clone novel cancer-related genes. We have developed …

Methylation of CpG islands in gene promoter regions is a major molecular mechanism of
gene silencing and underlies both cancer development and progression. In molecular …

To assess alterations in DNA methylation density in both global DNA and within CpG
islands, we have developed a simple method based on the use of methylation-sensitive …

Precise mapping of DNA methylation patterns in CpG islands has become essential for
understanding diverse biological processes such as the regulation of imprinted genes, X …

We present a straightforward and comprehensive approach for DNA methylation analysis in
mammalian genomes. The methylated-CpG island recovery assay (MIRA), which is based …