A second gene for autosomal dominant polycystic kidney disease (ADPKD), PKD2, has
been recently identified. Using antisera raised to the human PKD2 protein, polycystin-2, we …

Polycystin, the product of autosomal dominant polycystic kidney disease (ADPKD) 1 gene
(PKD1) is the cardinal member of a novel class of proteins. As a first step towards …

The gene PKD I, which is mutated in type I autosomal dominant polycystic kidney disease
(ADPKD 1), encodes a large protein of novel structure and unknown function and …

Mutations in PKD1 and PKD2, the genes that encode polycystin-1 and polycystin-2
respectively, account for almost all cases of autosomal dominant polycystic kidney disease …

Polycystic kidney disease 1 (PKD1) is the major locus of the common genetic disorder
autosomal dominant polycystic kidney disease. We have studied PKD1 mRNA, with an …

Abstract Autosomal Dominant Polycystic Kidney Disease (ADPKD), a common inherited
disease leading to progressive renal failure, can be caused by a mutation in either the PKD1 …

The most common form of autosomal dominant polycystic kidney disease (PKD) results from
mutation of the PKD1 gene on chromosome 16p13. 3. The gene encodes a 14-kb …

The polycystic kidney disease-1 gene, which is mutated in the majority of patients with
autosomal dominant polycystic kidney disease, has been identified. The protein encoded by …

The cloning of the PKD1 and PKD2 genes has led to promising new insight into the
mechanisms that are responsible for cyst development in patients with autosomal dominant …

The functions of the two proteins defective in autosomal dominant polycystic kidney disease,
polycystin-1 and polycystin-2, have not been fully clarified, but it has been hypothesized that …