Publisher Summary This chapter summarizes the recent structural and biochemical
advances in the study of mammalian DNA MTases and their associated protein factor (s) …

The term epigenetic modification denotes reversible traits of gene expression that do not
include alterations to the DNA sequence. These epigenetic alterations are responsible for …

The methylation of mammalian DNA, primarily at CpG dinucleotides, has long been
recognized to play a major role in controlling gene expression, among other functions. Given …

DNA methylation plays a central role in development serving as a tissue-specific, cell type-
specific, and developmental stage-specific memory mark overlaid on genetics, the sequence …

During differentiation and development cells undergo dramatic morphological and functional
changes without any change in the DNA sequence. The underlying changes of gene …

Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in
the mammalian genome and is essential for embryonic viability. With several of the key …

Although essentially all cells of a mammalian organism contain the same genetic
information they may differ dramatically in form and function. This cellular differentiation is …

DNA methylation is an essential part of the epigenome chromatin modification network,
which also comprises several covalent histone protein post-translational modifications. All …

In mammals, CpG methylation patterns are established and maintained during development
by the Dnmt1 and Dnmt3 families of DNA methyltransferases. These enzymes share …

Mammalian genomes are methylated on carbon-5 of many cytosines, mostly in CpG
dinucleotides. Methylation patterns are maintained during mitosis via DNMT1, and …