Introduction In the absence of a licensed formulation in many countries worldwide,
ADV6209, an innovative 2 mg/ml oral solution of midazolam containing cyclodextrin, has …

Purpose The objective of this study was to assess the bioavailability and the sedative effect
of a single-dose administration of an innovative oral solution of midazolam containing γ …

Midazolam is one of many bitter drugs where provision of a suitable oral paediatric
formulation, particularly in the pre‐anaesthetic setting, remains a challenge. To overcome …

Ozalin®, a novel oral solution of 0.2% midazolam, is an effective option for moderate
sedation prior to a therapeutic or diagnostic procedure, and as premedication before …

What is known and Objectives: Subjects of different ethnic groups may respond differently to
drugs. The present study was conducted to compare the oral pharmacokinetics of …

The first‐dose pharmacokinetics of midazolam and its primary α‐hydroxy metabolite were
studied after single‐dose administration. Eligible study patients were enrolled into one of …

Abstract Background and Objectives Midazolam rectal gel is a novel rectal formulation that
may be a promising and potential alternative to oral administration for pediatric sedation …

Abstract Background and Objective Midazolam is the preferred clinical probe drug for
assessing CYP3A activity. We have previously shown substantial intraindividual variability in …

Sublingually administered midazolam is commonly used for premedication of pediatric
patients. However, the irritating taste and low aqueous solubility of midazolam complicate its …

The aim of the study was to study a possible pharmacokinetic-pharmacodynamic (PK-PD)
relationship for midazolam in pediatric intensive care patients and to determine how …