Pharmacokinetics of midazolam: comparison of sublingual and intravenous routes in rabbit

P Odou, C Barthelemy, D Chatelier, M Luyckx… - European journal of …, 1999 - Springer
In France, the legal routes used to administer midazolam to a patient are intravenously and
intramuscularly. For anaesthetists, these routes are not well adapted to paediatric use; they …

Development and formulation of a 0.2% oral solution of midazolam containing γ-cyclodextrin

F Marçon, D Mathiron, S Pilard… - International journal of …, 2009 - Elsevier
In absence of dedicated children formulation, intravenous formulations of midazolam, which
exhibit strong bitterness, are occasionally used for oral or sublingual administration. In order …

Midazolam premedication in children: a comparison of two oral dosage formulations on sedation score and plasma midazolam levels

KK Brosius, CF Bannister - Anesthesia & Analgesia, 2003 - journals.lww.com
We compared two available oral formulations of midazolam with respect to sedation score
and plasma midazolam levels in pediatric surgical patients 2–10 yr old. The commercially …

Pediatric pharmacodynamics of midazolam oral syrup

J Marshall, A Rodarte, J Blumer… - The Journal of …, 2000 - Wiley Online Library
In this study, the authors evaluate the pharmacodynamics, safety, and acceptability of a new
cherry‐flavored oral syrup formulation of midazolam. This randomized, double‐blind …

Development and validation of a sensitive assay for analysis of midazolam, free and conjugated 1-hydroxymidazolam and 4-hydroxymidazolam in pediatric plasma …

GS Moorthy, H Jogiraju, C Vedar, AF Zuppa - Journal of Chromatography B, 2017 - Elsevier
Pharmacokinetic, pharmacodynamic and pharmacogenomic studies of midazolam are
currently being performed in critically ill children to find suitable dose regimens. Sensitive …

Pharmacokinetics of midazolam in Mexicans evidence for interethnic variability

L Chávez-Teyes, G Castañeda-Hernández… - Clinical drug …, 1999 - Springer
Objective: To determine midazolam pharmacokinetics in healthy Mexican volunteers and to
compare them with the pharmacokinetics reported for other populations. Patients and …

Development of midazolam sublingual tablets: in vitro study

P Odou, C Barthelemy, H Robert - European journal of drug metabolism …, 1998 - Springer
Midazolam is a benzodiazepine with short elimination half-life, used as induction or
continuous agent for general anesthesia. At present, only injectable solution is available …

The effect of age on the pharmacokinetics and pharmacodynamics of midazolam

S Albrecht, H Ihmsen, W Hering… - Clinical …, 1999 - Wiley Online Library
Objective We investigated the pharmacologic properties of midazolam with special regard to
age using the electroencephalogram (EEG) as a measure of the hypnotic‐sedative effect …

Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents

A van Rongen, JD Vaughns, GS Moorthy… - British journal of …, 2015 - Wiley Online Library
Aim In view of the increasing prevalence of obesity in adolescents, the aim of this study was
to determine the pharmacokinetics of the CYP3A substrate midazolam and its metabolites in …

Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients

SN De Wildt, M De Hoog, AA Vinks… - Critical care …, 2003 - journals.lww.com
Interventions The pharmacokinetics of midazolam and metabolites were determined during
and after a continuous infusion of midazolam (0.05–0.4 mg/kg/hr) for 3.8 hrs to 25 days …