Melatonin has been proposed as regulating the immune system by affecting cytokine
production in immunocompetent cells, enhancing the production of several T helper (Th) 1 …

Human lymphocytes have recently been described as an important physiological source of
melatonin (N‐acetyl‐5‐methoxytryptamine), which could be involved in the regulation of the …

It is well known that melatonin plays a fundamental role in human neuro‐
immunomodulation. Thus, melatonin regulates the production of a large number of …

Melatonin could act on immune system by regulating cytokine production of
immunocompetent cells. The hormone enhances IL-2, IFN-γ and IL-6 production by cultured …

In mammals, the pineal hormone melatonin activates G protein-coupled MT1 and MT2
melatonin receptors. Acute exposure of recombinant MT1 and MT2 melatonin receptors to …

This report shows that melatonin enhances IL‐2 production by Jurkat cells via a nuclear
receptor‐mediated mechanism. Jurkat cells express nuclear (RZRα, RORα1, and RORα2) …

Aim: To investigate the expression of membrane melatonin receptors in murine thymocytes,
CD4+ T-cells, bone marrow cells and B-cells according to melatonin concentration in the …

Mast cells take part of armamentarium immunologic for host defense against parasitic and
bacterial infections. They are derived from bone marrow progenitors and can be activated by …

Human lymphocyte melatonin, through membrane and nuclear receptors binding, acts as an
activator in IL-2 production. Antagonism of membrane melatonin receptors using luzindole …

Melatonin binds and activates G protein‐coupled melatonin receptors. The density and
affinity of the endogenous melatonin receptors change throughout the 24‐hr day, and the …