After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools
available to interrogate it, we consider the literature surrounding DNA methylation as …

Aberrant DNA methylation is one of the hallmarks of carcinogenesis and has been
recognized in cancer cells for more than 20 years. The role of DNA methylation in malignant …

Epigenetic alterations contribute significantly to the development and progression of
prostate cancer, the most prevalent malignant tumor in males of Western industrialized …

Prostate cancer is the most common malignancy and the second leading cause of cancer
death among men in the United States. There are three well-established risk factors for …

Promoter hypermethylation is associated with the loss of expression of tumor-suppressor
genes in cancer. Currently, several genome-wide technologies are available and have been …

Introduction 3. DNA methylation in prostate cancer 3.1. DNA Hypermethylation 3.1. 1.
Hormonal response genes 3.1. 2. Cell cycle control genes 3.1. 3. Tumor invasion and tumor …

Prostate cancer (PCa) is the most prevalent cancer, a significant contributor to morbidity and
a leading cause of cancer-related death in men in Western industrialized countries. In …

Background: Prostate cancer (PCa) harbors a myriad of genomic and epigenetic defects.
Cytosine methylation of CpG-rich promoter DNA is an important mechanism of epigenetic …

Prostate cancer is a major cause of cancer‐related deaths among men worldwide. In
addition to genomic alterations, epigenetic alterations accumulated in prostate cancer have …

We examined the DNA methylation pathway in an autochthonous murine prostate cancer
model, transgenic adenocarcinoma of mouse prostate (TRAMP). We observed that …