Background Methylation of high-density CpG regions known as CpG Islands (CGIs) has
been widely described as a mechanism associated with gene expression regulation …

Background: The role of global DNA methylation in prostate cancer (PCa) remains largely
unknown. Our aim was to summarize evidence on the role of global DNA hypomethylation in …

Cancer is often viewed as a genetic process in which the developing cancer cell acquires
successive mutational lesions that each provide the cell with a growth or survival advantage …

Publisher Summary This chapter discusses the role of DNA methylation in carcinogenesis
and tumor diversification. The methylation of HpaII and Hha1 sites in DNA isolated from the …

The phenotype of the cancerous cell may arise either from genetic alterations that disrupt
gene function through sequence modifications (mutations) or epigenetic events that may …

Human cancers almost ubiquitously harbor epigenetic alterations. Although such alterations
in epigenetic marks, including DNA methylation, are potentially heritable, they can also be …

The main thrusts of the arguments that aberrant DNA methylation is involved in the
generation of tumor heterogeneity and progression can be summarized as follows. The …

Purpose Detection of DNA hypermethylation has emerged as a novel molecular biomarker
for prostate cancer diagnosis and evaluation of prognosis. We sought to define whether a …

Next year will mark 60 years since Dr. Leslie Foulds outlined his hypothesis that cancer is “a
dynamic process advancing through stages that are qualitatively different,” leading the way …

Purpose: Prostate cancer is a leading cause of cancer death among the aging male
population but the mechanism underlying this association is unclear. Aberrant methylation of …